Exciting new work on Bi2Sr2CaCu2O8+delta (Bi2212) shows the presence of nontrivial spin-orbit coupling effects as seen in spin-resolved angle-resolved photoemission spectroscopy data [K. Gotlieb et al., Science 362, 1271 (2018)]. Motivated by these observations we consider how the picture of spin-orbit coupling through local inversion symmetry breaking might be observed in cuprate superconductors. Furthermore, we examine two spin-orbit driven effects, the spin-Hall effect and the Edelstein effect, focusing on the details of their realizations within both the normal and superconducting states.