The spectral form factor (SFF), characterizing statistics of energy eigenvalues, is a key diagnostic of many-body quantum chaos. In addition, partial spectral form factors (PSFFs) can be defined which refer to subsystems of the many-body system. They provide unique insights into energy eigenstate statistics of many-body systems, as we show in an analysis on the basis of random matrix theory and of the eigenstate thermalization hypothesis. We propose a protocol that allows the measurement of the SFF and PSFFs in quantum many-body spin models, within the framework of randomized measurements. Aimed to probe dynamical properties of quantum many-body systems, our scheme employs statistical correlations of local random operations which are applied at different times in a single experiment. Our protocol provides a unified test bed to probe many-body quantum chaotic behavior, thermalization, and many-body localization in closed quantum systems which we illustrate with numerical simulations for Hamiltonian and Floquet many-body spin systems.