We study multiband semiconducting nanowires proximity-coupled with an s-wave superconductor. We show that, when an odd number of subbands are occupied, the system realizes a nontrivial topological state supporting Majorana modes. We study the topological quantum phase transition in this system and calculate the phase diagram as a function of the chemical potential and magnetic field. Our key finding is that multiband occupancy not only lifts the stringent constraint of one-dimensionality but also allows one to have higher carrier density in the nanowire, and as such multisubband nanowires are better suited for observing the Majorana particle. We study the robustness of the topological phase by including the effects of the short- and long-range disorder. We show that there is an optimal regime in the phase diagram ("sweet spot") where the topological state is to a large extent insensitive to the presence of disorder.