Recent experiments have observed possible spin- and valley-polarized insulators and spin-triplet superconductivity in twisted double bilayer graphene, a moire structure consisting of a pair of Bernal-stacked bilayer graphene. Besides the continuously tunable bandwidths controlled by an applied displacement field and twist angle, these moire bands also possess Van Hove singularities near the Fermi surface and a field-dependent nesting which is far from perfect. Here we carry out a perturbative renormalization group analysis to unbiasedly study the competition among all possible instabilities in twisted double bilayer graphene and related systems with a similar Van Hove fermiology in the presence of weak but finite repulsive interactions. Our key finding is that there are several competing magnetic, valley, charge, and superconducting instabilities arising from interactions in twisted double bilayer graphene, which can be tuned by controlling the displacement field and the twist angle. In particular, we show that spin- or valley-polarized uniform instabilities generically dominate under moderate interactions smaller than the bandwidth, whereas p-wave spin-triplet topological superconductivity and exotic spin-singlet modulated paired state become important as the interactions decrease. Realization of our findings in general moire systems with a similar Van Hove fermiology should open up new opportunities for manipulating topological superconductivity and spin- or valley-polarized states in highly tunable platforms.